• Research Associate/ Sr. Research Associate, Upstream Fermentation

    Job Locations US-MA-Bedford
    Upstream PD
    Full Time Salary
  • Overview

    Homology Medicines seeks an outstanding Research or Senior Research Associate in the Upstream Process Development team to assist in the development of plasmid manufacturing processes and scale-up strategies. The individual in this role will be a highly-skilled, talented and motivated researcher who will focus on the scale up of bacterial methods for producing DNA plasmids. We seek candidates with proven ability to work independently after initial training and collaboratively to achieve optimized project plans, with the goal to deliver products that transform the lives of patients.


    • Characterize scale-up processes for bacterial production of DNA plasmids in shake flasks and fermenters
    • Evaluate feed strategies for improving plasmid production
    • Collaborate on development of harvest, clarification and filtration strategies
    • Develop and write standardized fermentation protocols
    • Author technical reports and tech transfer documents as needed


    • BS or equivalent with 2+ years industry experience or MS in relevant field
    • Familiarity with lab-scale bacterial production platforms up to 50L
    • Experience in filtration and/or tangential flow filtration also preferred
    • Adept at conducting routine testing and limited troubleshooting of multiple methods
    • Able to effectively manage and prioritize multiple parallel laboratory activities is essential
    • Able to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view
    • Independently motivated, detail oriented and good problem-solving ability
    • Excellent interpersonal written and oral communication skills


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