• Scientist /Senior Scientist – Upstream transfection development

    Job Locations US-MA-Bedford
    Upstream PD
    Full Time Salary
  • Overview

    Homology Medicines seeks an outstanding Scientist/Senior Scientist in the Upstream Process Development team with knowledge of transfection mediated production of biological products. The individual in this role will be a highly-skilled, talented and motivated scientist who will focus on optimizing transfection and cell culture parameters critical to recombinant AAV production. We seek candidates with proven ability to work independently in the lab and collaboratively to achieve optimized project plans, with the goal to deliver products that transform the lives of patients.


    • Develop novel methods for evaluating and optimizing transfection complex formation, plasmid uptake, and cellular trafficking
    • Define critical parameters for cellular transfection at multiple production scales and platforms
    • Cellular and molecular characterization AAV production process using metabolic profiling and molecular techniques (ddPCR, ELISA, etc)
    • Develop laboratory protocols and provide technical support and training to others
    • Assists with the development of project strategy and communicates complex data/decisions within department and cross functionally as necessary


    • BS (4+), MS (2+), or PhD (0+) years industry experience
    • Degree experience in biochemistry, cellular biology, or molecular biology
    • Experience with AAV or other viral products is preferred
    • Previous production of biologic products in a mammalian cell culture system
    • Techniques including qPCR or ddPCR, ELISA, flow cytometry, and particle size analysis
    • Able to effectively manage and prioritize multiple parallel laboratory activities is essential
    • Excellent interpersonal written and oral communication skills and ability to work as part of multidisciplinary teams


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