• Associate Director, Plasmid Manufacturing

    Job Locations US-MA-Bedford
    ID
    2019-1071
    Category
    Upstream PD
    Type
    Full Time Salary
  • Overview

    Homology Medicines seeks an outstanding Associate Director in the Upstream Process Development team to oversee the development of plasmid DNA production and purification manufacturing platforms. The individual in this role will be a highly-skilled, talented and motivated scientist who will focus on leading a new team to aid in the development, characterization, and scale up of methods for producing and purifying plasmid DNA. We seek candidates with proven ability to work independently in the lab and collaboratively to achieve optimized project plans, with the goal to deliver products that transform the lives of patients.

    Responsibilities

    • Lead and manage a team in the development of upstream fermentation and downstream purification for DNA plasmids
    • Plan and execute studies related to bacterial fermentation and yield improvements
    • Develop and execute process steps related to cell lysis and clarification
    • Coordinate experiments to develop multiple chromatography-based purification for product capture and enrichment
    • Evaluate raw materials and equipment ensuring scalability and compatibility with GMP operations and tech transfer
    • Interact with external partners to review data and batch records
    • Develop SOP’s, batch records, and provide technical support and training to others

    Qualifications

    • BS (12+), MS (10+), or PhD (6+) years industry experience. Degree experience in microbiology, biochemistry, or molecular biology.
    • Previous production or purification of biologic products in bacterial culture systems
    • Direct management experience of research or development teams is required
    • Industry experience in the manufacturing of DNA products in fermentation bioreactors strongly preferred
    • Molecular techniques including DNA sequencing, restriction digest analysis, gel electrophoresis, and ELISAs
    • Proven leadership experience and management skills with ability to work in a fast-paced, highly collaborative environment
    • Strong verbal and written communication skills

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