• Scientist/ Sr. Scientist – Plasmid Production and Purification

    Job Locations US-MA-Bedford
    ID
    2019-1047
    Category
    Upstream PD
    Type
    Full Time Salary
  • Overview

    Homology Medicines seeks an outstanding Scientist/Senior Scientist in the Upstream Process Development team to oversee the development of plasmid DNA product manufacturing platforms. The individual in this role will be a highly-skilled, talented and motivated scientist who will focus on building out a new team to aid in the development, characterization, and scale up of methods for producing and purifying plasmid DNA. We seek candidates with proven ability to work independently in the lab and collaboratively to achieve optimized project plans, with the goal to deliver products that transform the lives of patients.

    Responsibilities

    • Establish key engineering parameters for DNA production including bacterial cell culture and fermentation, harvest, feed strategies, and lysis and clarification
    • Proven expertise in purification methods, including with chromatographic purification or HPLC evaluation using IEX or HIC
    • Evaluate raw materials and equipment ensuring scalability and compatibility with GMP operations and tech transfer
    • Proven leadership experience and management skills with ability to work in a fast-paced, highly collaborative environment
    • Develop SOP’s, batch records, and provide technical support and training to others
    • Ability to support regulatory documentation from needed for submissions

    Qualifications

    • BS (6+), MS (3+), or PhD (1+) years industry experience. Degree experience in biochemistry, chemistry, or molecular biology
    • Must have purification experience with anion exchange or hydrophobic interaction chromatography
    • Previous production of biologic products in bacterial culture systems
    • Industry experience in the manufacturing of DNA products in fermentation bioreactors
    • Molecular techniques including DNA sequencing, restriction digest analysis, gel electrophoresis, and ELISAs
    • Able to effectively manage and prioritize multiple parallel laboratory activities is essential
    • Excellent interpersonal written and oral communication skills and ability to work as part of multidisciplinary teams

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